Part:BBa_K4610002

The part BBa_K4510002, Afu8g00480, is a segment of DNA that encodes for the synthesis of the protein dioxygenase af480/Fumagillin biosynthesis cluster C-6 hydroxylase (Fma-C6H). In the fumagillin biosynthesis pathway, Fma-C6H is used for the hydroxylation of 5-keto-demethoxy fumagillol. More specifically, after the three step oxidation involving Fma-P450 (BBa_K4610001), Fma-C6H is used for a hydroxylation of 5-keto-demethoxy fumagillol. Subsequently, Fma-MT (Afu8g00390, BBa_K4610003) is used for the methylation of 5-keto-demethoxy fumagillol (Guruceaga et. al 2020).